Survey Results Highlight Burden of Neurogenic Orthostatic Hypotension (nOH)

nOH is defined as a sustained drop in blood pressure upon standing that is due to autonomic dysfunction and is often associated with an underlying neurodegenerative disorder, such as Parkinson’s disease. Symptoms of nOH may include dizziness, lightheadedness, fatigue, blurred vision, and others that occur upon standing.

Who Is Affected?

Stats about noh: About 1 in 5 people with PD may also have symptoms of nOH
Stats about noh: About 4 out of 5 people with MSA may also have symptoms of nOH
Stats about noh: Nearly 100% of people with PAF have symptoms of nOH

nOH Symptoms May Affect Daily Activities

Stats about noh: 87% of patients said that nOH symptoms had an overall negative impact on their ability

of patients said that nOH symptoms had an overall negative impact on their ability to perform daily activities

“My nOH symptoms can make daily activities physically challenging. Sometimes I get dizzy after long periods of standing and need to sit down.”

—Leon, a PD patient living with nOH

Stats about noh: Up to 53% of patients reported reducing or stopping some daily activities

of patients reported reducing or stopping some daily activities

Stats about noh: 85% of care partners said that patients needed assistance

of care partners said that patients needed assistance with day-to-day activities in the past month

Stats about noh: 60% of patients somewhat or strongly agreed that they often hide or minimize their nOH symptoms

of patients somewhat or strongly agreed that they often hide or minimize their nOH symptoms

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Stats about noh: 55% of patients and care partners somewhat or strongly agreed that patients did not hesitate a discussion about their nOH symptoms

of patients and care partners somewhat or strongly agreed that patients did not initiate a discussion about their nOH symptoms with their healthcare provider unless the symptoms were severe

The authors designed a closed-ended, multiple choice set of questions related to patient nOH symptomology and perception of disease burden. The survey was conducted online by Harris Poll between August 26, 2016 and October 3, 2016 on behalf of Lundbeck. Patient organizations including The Michael J. Fox Foundation for Parkinson’s Research, American Parkinson Disease Association, Davis Phinney Foundation, MSA Coalition, National Parkinson Foundation, and Parkinson’s Disease Foundation helped to recruit patients for the US-based survey. Survey respondents included 363 patients and 128 care partners, and primary diagnosis of Parkinson’s disease was self-selected in 90 percent of patients. In addition, 10 percent of patients reported multiple system atrophy and 4 percent reported pure autonomic failure. Similar rates of patient diagnosis were reported by care partners. Despite meeting survey criteria, a formal diagnosis of OH or nOH was reported by 36 percent of patients. This study represents the views of a limited sample of nOH patients and may not be representative of all patients with nOH. Other limitations of this study include that care partners were not required to be paired with patients included in the survey, so it is not possible to draw conclusions regarding the consistency of responses between patients and their care partners.